The Office of Clinical Cancer Proteomics supports proteogenomic science and technologies across the nation and around the world to uncover the molecular mechanisms of cancer and better inform patient care.
Office of Clinical Cancer Proteomics Research Programs
Clinical Proteomic Tumor Analysis Consortium (CPTAC)
The Clinical Proteomic Tumor Analysis Consortium is a national effort that applies proteogenomic strategies to advance precision oncology. The CPTAC network was created to improve upon problems in the field of clinical proteomics, including a lack of standardized methodologies, comparable data, and quality reagents. CPTAC holds its members to a high level of analytical rigor while providing community resources like the CPTAC data, assays, and antibody portals.
International Cancer Proteogenome Consortium (ICPC)
The International Cancer Proteogenome Consortium uses CPTAC-based workflows to use proteogenomics to understand cancer biology and predict treatment response. The global network allows for sampling among diverse patients and commonly diagnosed cancers in their unique populations. The The Consortium provides a forum for collaboration among the world's leading cancer research centers and unifies methodologies on a global scale. The ICPC supports public data sharing around the world to accelerate translation of results to patient care.
Applied Proteogenomic OranizationaL Learning and Outcomes (APOLLO)
The Applied Proteogenomic OranizationaL Learning and Outcomes network is a collaboration between NCI, the Department of Defense (DoD), and the Department of Veterans Affairs (VA) to incorporate CPTAC-developed proteogenomic workflows into patient care. Partnering with the nation's two larges healthcare systems, DoD and VA, allows NCI to continuously study cancer patients throughout their treatment and into remission. De-identified proteogenomic data collected in the study are made publicly available across NCI data sharing platforms.
Proteogenomics Research: On the Frontier of Precision Medicine
Learn about how CSSI’s Office of Clinical Cancer Proteomics is integrating cancer genomics and proteomics (termed proteogenomics) and how proteogenomics is anticipated to improve precision medicine.
International Cancer Proteogenome Consortium
Learn about the International Cancer Proteogenome Consortium (ICPC) and how it’s breaking down silos to advance proteogenomic cancer research worldwide.