Engineering Biology for Cancer Applications

NCI and NIBIB have issued a new funding opportunity, “Collaborative Approaches to Engineer Biology for Cancer Applications (U01 Clinical Trial Not Allowed)” – RFA-CA-20-054. The RFA solicits applications that develop and apply innovative synthetic biology approaches to address challenges across the continuum of cancer research. Projects will be required to define an important cancer research question and then approach that question with a synthetic biology technology, based on an adapted biological system that can sense input, apply logic to determine a response to the input, and initiate a response. The emphasis is on both the significance of the cancer research question and the innovation and potential of the technical approach. Transdisciplinary teams with expertise in cancer research and engineering or other disciplines relevant to synthetic biology are expected.

The goal of the FOA is to support synthetic biology approaches for cancer research that will expand technology development, promote transdisciplinary partnerships, and spur new efforts to advance mechanistic understanding of cancer and possibilities for cancer management.

Letters of Intent Due: December 16, 2020
Applications Due: January 15, 2021 at 5:00pm local time of applicant.

A pre-application webinar NOT-CA-21-017 was held on December 10, 2020.
Slides from the webinar here
Frequently Asked Questions here

Please direct any questions to Michelle Berny-Lang at

Webinar Video