About Us

About Us


The Center for Strategic Scientific Initiatives (CSSI) is a research office of the National Cancer Institute (NCI). CSSI acts as a concept shop for the NCI, investing in exploratory research and creating opportunities for researchers through the development of new science initiatives, tools, and public resources.

The National Cancer Institute, part of the National Institutes of Health (NIH), is the federal government's principal agency for cancer research and training. NCI’s mission is to lead, conduct, and support cancer research across the nation to advance scientific knowledge and help all people to live longer, healthier lives. NCI’s scope of work spans a broad spectrum of cancer research across a variety of disciplines and supports research training opportunities at career stages across the academic continuum.

CSSI Office of the Director oversees all scientific and programmatic activities of CSSI to carry out the mission of the Center. CSSI OD directly manages two trans-NCI grant programs, the Innovative Molecular Analysis Technologies (IMAT) program and the Provocative Questions (PQ) initiative. It also develops and oversees several pilot programs focused on technology development, preanalytical variables and standards, and training.

The Office of Cancer Clinical Proteomics Reserach supports initiatives using proteomic data to better understand the molecular mechanisms of cancer and streamlines the translation of proteomic discoveries into the clinic. OCCPR programs include the Clinical Proteomic Tumor Analysis Consortium (CPTAC), the International Cancer Proteomics Consortium (ICPC), and the Applied Proteogenomics OrganizationaL Learning and Outcomes (APOLLO) network.

The Knowledge Management and Special Projects Branch oversees the reporting of the NCI-funded portfolio of grants, intramural, and contract projects. KMSPB serves as the NCI lead for all official NIH Research, Condition, and Disease Categorization (RCDC) reporting for NCI-funded research. KMSPB also manages the NCI Funded Research Portfolio (NFRP) website and database to ensure the completeness, timeliness, and accuracy of scientific funding data.

Learn more about CSSI: