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Projects as of December 2021
| Focus* | Project | Lead Investigator(s) | Date Approved | Status |
|---|---|---|---|---|
| Health Outcomes | Blood metabolomic profiling in prostate cancer risk | Demetrius Albanes | Fall 2017 | Ongoing |
| Health Outcomes | Blood metabolites profiling in malignant glioma risk | Demetrius Albanes | Fall 2017 | Ongoing |
| Metabolite(s)-Focused | Levels of trimethylamine metabolites and their associations with dietary and non-dietary factors Click the plus sign below to expand the section and view the project publications
|
Danxia Yu | Fall 2017 | Complete |
| Exposures and Genetics | Genetic influences on the human metabolome | Bing Yu | Fall 2017 | Ongoing |
| Exposures and Genetics | The metabolome of overweight and obesity | Rachel Kelly | Fall 2017 | Ongoing |
| Health Outcomes |
Metabolomics of blood pressure regulation |
Christina Menni | Fall 2017 | Ongoing |
| Health Outcomes | Metabolomic profiles of dietary factors implicated in cancer etiology |
Mary Playdon and Steven Moore |
Spring 2018 | Ongoing |
| Exposures and Genetics | Genetics, metabolomics and cardiovascular disease risk | Bing Yu and Cristina Menni | Spring 2018 | Ongoing |
| Health Outcomes | Metabolomic profile of type 2 diabetes: the COnsortium of METabolomics Studies (COMETS) | Nicholette Allred and Meghana Gadgil | Spring 2018 | Ongoing |
| Exposures and Genetics | Genetic analysis and causal inference for untargeted signals from MS-based metabolite profiles |
Joel Hirschhorn |
Spring 2018 | Ongoing |
| Metabolite(s)-Focused | Genes, environment, and metabolic disease - convergence on ceramides | Scott Summers and Mary Playdon | Spring 2018 | Ongoing |
| Health Outcomes | Metabolomic profiles and pancreatic cancer risk | Rachael Z. Stolzenberg-Solomon | Spring 2018 | Ongoing |
| Health Outcomes | Metabolomic profiles of inflammatory & insulinemic dietary patterns and colorectal cancer risk | Fred Tabung | Winter 2019 | Ongoing |
| Health Outcomes | Blood metabolomics and lung cancer risk | Wei Jie Seow | Winter 2019 | Ongoing |
| Health Outcomes | Metabolomics of symptomatic gallstone disease in COMETS | Amit Joshi | Spring 2019 | Ongoing |
| Exposures and Genetics | Blood metabolites and their association with age: A COMETS study | Steve Moore | Spring 2019 | Ongoing |
| Metabolite(s)-Focused | Metabolomic profiles of circulating micronutrients and vitamin/nutritional supplements | Demetrius Albanes | Summer 2019 | Ongoing |
| Methods | Genetic imputation of metabolomics data | Burcu Darst | Summer 2019 | Ongoing |
| Exposures and genetics | Biomarkers of exposure and response to coffee Intake | Marc Gunter | Summer 2019 | Ongoing |
| Health Outcomes | Metabolic health and obesity-relevant diseases | Mary Playdon | Summer 2019 | Ongoing |
| Health Outcomes | Genetic metabolite scores for prediction of incident and prevalent cardiometabolic and pulmonary disease | Nasa Sinnott-Armstrong | Summer 2019 | Ongoing |
| Health Outcomes | Sex differences in the metabolome | Raji Balasubramanian | Winter 2020 | Ongoing |
| Exposures and genetics | A metabolomic characterization of APOE genotype using the COnsortium of METabolomics Studies | Megan Marron | Winter 2020 | Ongoing |
| Health Outcomes | Metabolomic profiles of subclinical atherosclerosis | Bing Yu | Spring 2020 | Ongoing |
| Health Outcomes | Metabolomic profiles of colorectal cancer | Jennifer Ose | Summer 2020 | Ongoing |
| Health Outcomes | Prospective metabolomics study of gastric cancer | Xiang Shu | Summer 2020 | Ongoing |
| Health Outcomes | Consequences of air quality on cardiometabolic and pulmonary disease | Nasa Sinnott-Armstrong | Summer 2020 | Ongoing |
| Health Outcomes | Novel metabolomic pathways for hyperuricemia and gout | Hyon K. Choi | Winter 2021 | Ongoing |
| Health Outcomes | Metabolomics of asthma, chronic obstructive pulmonary disease, lung function and allergy phenotypes: a COnsortium of METabolomics Studies (COMETS) analysis | Jessica Lasky-Su, Rachel Kelly and Bo Chawes on behalf of the COMETS Lung IG | Winter 2021 | Ongoing |
| Health Outcomes | Adulthood weight change, blood metabolomic profiles and lung function | Hyung-Suk Yoon | Winter 2021 | Ongoing |
| Health Outcomes | Magnesium-modifiable, microbial metabolites in association with diet, type 2 diabetes, and coronary heart disease | Danxia Yu | Winter 2021 | Ongoing |
| Metabolite(s)-Focused | Examination of vitamin D-associated and other metabolites in relation to cancer risk and mortality by race and ethnicity | Wayne R. Lawrence and Gieira S. Jones | Summer 2021 | Ongoing |
| Metabolite(s)-Focused | Dietary metabolomics in the COnsortium of METabolomics Studies | Mary C. Playdon on behalf of the COMETS Diet IG | Summer 2021 | Ongoing |
| Health Outcomes | Metabolome profile associated with interstitial lung abnormalities | Scott Matson | Winter 2022 | Ongoing |
* Projects are classified according to the following focus areas: (1) Health outcomes projects are focused on associations between metabolites and diseases/other health outcomes; (2) Exposures and genetics projects are focused on the interrelationships among exposures, or genetics and metabolites; (3) Metabolite(s)-focused projects will assess the interrelationships between exposures or genetics and specific metabolites (or classes of metabolites) and their role on health outcomes; (4) Methods projects will address analytical, platform, harmonization, statistical or other methodologic topics.